Calorie-reduced mediterranean diet with exercise cuts diabetes risk by 31 percent

A major Spanish clinical trial has shown that a modified Mediterranean diet, combined with calorie restriction, physical activity and professional support, reduced the risk of type 2 diabetes by 31 percent over six years. The findings come from the PREDIMED-Plus study involving nearly 5,000 adults with overweight or obesity.

Researchers followed 4,746 participants aged 55 to 75 who had metabolic syndrome but no diabetes at the outset. One group adopted a calorie-reduced Mediterranean diet, added moderate exercise such as brisk walking, and received coaching on weight loss. The comparison group followed a standard Mediterranean diet without these additions.

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Pediatrician assessing overweight children in clinic, highlighting study-recommended early treatment to prevent adult risks like diabetes and hypertension.
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Study recommends treatment for all children with obesity

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A new Karolinska Institutet study finds that children with moderate obesity face higher risks of type 2 diabetes, high blood pressure, and lipid disorders in adulthood, even without apparent risk markers. Researchers urge treatment for all such children.

New research published in Nature Medicine reveals that people with prediabetes can normalize blood sugar levels without losing weight. About one in four participants in lifestyle programs achieved this remission, offering protection against diabetes similar to weight loss methods. The key factors involve fat distribution and certain hormones.

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A new study shows that a high-fat ketogenic diet can normalize blood sugar levels in mice with hyperglycemia and enhance their muscles' response to exercise. Led by researcher Sarah Lessard, the research indicates that combining the diet with physical activity leads to better oxygen use and endurance. The findings suggest potential benefits for metabolic health when diet and exercise are paired.

Scientists have developed a hybrid obesity treatment that uses GLP-1 and GIP signals to deliver a metabolic enhancer directly into cells. Early tests in mice showed greater weight loss and better blood sugar control than standard therapies. The approach aims to reduce side effects by limiting the drug's action to targeted areas.

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Researchers have identified why living at high altitudes reduces diabetes risk: red blood cells absorb excess glucose in low-oxygen conditions. This metabolic shift lowers blood sugar levels, as shown in mouse experiments. A new drug mimicking this effect reversed diabetes in mice, suggesting potential treatments.

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