Calorie-reduced mediterranean diet with exercise cuts diabetes risk by 31 percent

A major Spanish clinical trial has shown that a modified Mediterranean diet, combined with calorie restriction, physical activity and professional support, reduced the risk of type 2 diabetes by 31 percent over six years. The findings come from the PREDIMED-Plus study involving nearly 5,000 adults with overweight or obesity.

Researchers followed 4,746 participants aged 55 to 75 who had metabolic syndrome but no diabetes at the outset. One group adopted a calorie-reduced Mediterranean diet, added moderate exercise such as brisk walking, and received coaching on weight loss. The comparison group followed a standard Mediterranean diet without these additions.

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Intermittent energy restriction tied to shifts in brain activity and gut microbiome, small study suggests

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A small 2023 study of adults with obesity in China found that an intermittent energy restriction program was associated with weight loss and changes in gut bacteria alongside altered activity in brain regions linked to appetite, cravings and self-control.

A Brazilian study found that fish oil supplements reduced insulin resistance and inflammation in rats modeling non-obese type 2 diabetes. The research highlights a potential role for omega-3 fatty acids in cases where obesity is not a factor.

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