Experimental mRNA vaccine shows protection against multiple ebola viruses

English

An experimental mRNA vaccine has demonstrated effectiveness against three strains of Ebola virus in rodent tests. The vaccine targets Zaire, Sudan and Bundibugyo viruses. Researchers developed it amid an ongoing outbreak of Bundibugyo virus in Africa.

Yanfeng Yao and colleagues at the Wuhan Institute of Virology created the vaccine by combining mRNA sequences for glycoproteins from each virus along with a shared nucleoprotein inside a lipid nanoparticle. In tests, immunised mice gained complete protection against Zaire and Sudan viruses and strong protection against Bundibugyo. Hamsters also received full protection from Sudan virus exposure.

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