La semaglutida muestra resultados significativos en la pérdida de peso para adultos mayores de 65 años

Un nuevo análisis de ensayos clínicos indica que la semaglutida, el principio activo de Ozempic y Wegovy, ayuda a los adultos mayores con obesidad a perder una cantidad considerable de peso y a mejorar los marcadores de salud cardíaca. Los hallazgos provienen de datos de participantes de 65 años o más que recibieron el medicamento una vez por semana junto con cambios en el estilo de vida.

Investigadores dirigidos por el profesor Luca Busetto de la Universidad de Padua examinaron los resultados de los ensayos STEP 1, 3, 4, 5, 8 y 9. El análisis se centró en 358 adultos de 65 años o más con obesidad pero sin diabetes. De ellos, 248 tomaron 2,4 mg de semaglutida mientras que 110 recibieron un placebo durante 68 semanas.

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Realistic illustration contrasting social stigma: neutral for overweight, positive for exercise weight loss, negative for Ozempic users.
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Study finds people who use Ozempic-like drugs for weight loss face added stigma

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People who lose weight using GLP-1 medications such as Ozempic and Wegovy may be judged more negatively than those who lose weight through diet and exercise — and even more negatively than people who do not lose weight at all — according to a new study led by Rice University psychologist Erin Standen.

A large study tracking nearly 100,000 people in Sweden found that GLP-1 receptor agonists like semaglutide, sold as Ozempic and Wegovy, are associated with significantly fewer psychiatric hospital visits and reduced sick days due to mental health issues. Researchers observed drops of up to 47% in various mental health risks during drug use periods. The findings appear in The Lancet Psychiatry.

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A real-world study of nearly 8,000 patients by Cleveland Clinic researchers shows that stopping injectable semaglutide or tirzepatide often does not lead to major weight regain. Many participants maintained or continued losing weight by restarting treatment, switching medications, or using lifestyle support. This differs from clinical trials where rapid regain was observed.

Scientists have developed a hybrid obesity treatment that uses GLP-1 and GIP signals to deliver a metabolic enhancer directly into cells. Early tests in mice showed greater weight loss and better blood sugar control than standard therapies. The approach aims to reduce side effects by limiting the drug's action to targeted areas.

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Young Indians are turning to diabetes drugs Ozempic and Mounjaro for rapid weight loss before weddings and job interviews, as experts warn of cosmetic misuse, grey market dangers, and rising lookism. These GLP-1 drugs are meant for obesity and diabetes, not vanity purposes, doctors emphasize.

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