CRISPR
CRISPR-based epigenome editing switches genes on by removing methyl tags, without cutting DNA
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Researchers at UNSW Sydney and St. Jude Children’s Research Hospital report a CRISPR-derived “epigenome editing” approach that turns genes on by removing DNA methylation marks rather than cutting DNA. In cell-based experiments, they show that promoter methylation can directly—and reversibly—silence fetal globin genes, a finding they say helps settle a long-running debate about whether methylation is causal or merely correlated with gene shutdown. The work points to a potential path toward safer therapies for sickle cell disease by reactivating fetal hemoglobin without creating DNA breaks.
Nobel Prize-winning scientist Jennifer Doudna has cofounded Aurora Therapeutics, a startup focused on developing personalized gene-editing treatments for rare diseases. The company plans to leverage CRISPR technology and a new FDA regulatory pathway to bring these therapies to market. This initiative builds on recent successes in custom treatments that have saved lives.
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Lo specialista in economia della salute Martin Morgenstern ha dichiarato in un'intervista che l'editing genetico trasformerà i trattamenti medici nelle prossime decadi. Secondo lui, tecnologie come CRISPR permetteranno di alterare geni specifici per combattere condizioni come il colesterolo alto. Questo approccio promette di essere più preciso dei farmaci tradizionali, sebbene comporti rischi intrinseci.
Conservationists are divided over a proposed moratorium on genetic modification of wildlife at an upcoming International Union for Conservation of Nature meeting. While some groups seek a pause to assess risks, others argue that technologies like CRISPR are essential for saving endangered species. The vote could influence funding and policies worldwide.