Illustration of UC San Diego researchers' CRISPR pPro-MobV system spreading through bacterial biofilms to disable antibiotic resistance genes in a lab setting.
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UC San Diego researchers describe a gene-drive-like CRISPR system designed to reduce antibiotic resistance in bacteria

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Researchers at the University of California San Diego report they have developed a second-generation CRISPR-based “Pro-Active Genetics” system, called pPro-MobV, that is designed to spread between bacteria and disable antibiotic-resistance genes, including inside hard-to-treat biofilms.

Nobel Prize-winning scientist Jennifer Doudna has cofounded Aurora Therapeutics, a startup focused on developing personalized gene-editing treatments for rare diseases. The company plans to leverage CRISPR technology and a new FDA regulatory pathway to bring these therapies to market. This initiative builds on recent successes in custom treatments that have saved lives.

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Researchers at UNSW Sydney and St. Jude Children’s Research Hospital report a CRISPR-derived “epigenome editing” approach that turns genes on by removing DNA methylation marks rather than cutting DNA. In cell-based experiments, they show that promoter methylation can directly—and reversibly—silence fetal globin genes, a finding they say helps settle a long-running debate about whether methylation is causal or merely correlated with gene shutdown. The work points to a potential path toward safer therapies for sickle cell disease by reactivating fetal hemoglobin without creating DNA breaks.

Scientists have used CRISPR to edit a single gene in pigs, making them fully resistant to classical swine fever, a contagious disease that devastates livestock. This breakthrough could enhance animal welfare, boost productivity, and reduce emissions. The same edit may protect cattle and sheep from related viruses.

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Conservationists are divided over a proposed moratorium on genetic modification of wildlife at an upcoming International Union for Conservation of Nature meeting. While some groups seek a pause to assess risks, others argue that technologies like CRISPR are essential for saving endangered species. The vote could influence funding and policies worldwide.

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