Omega-3 fish oil shows promise against non-obese type 2 diabetes

A Brazilian study found that fish oil supplements reduced insulin resistance and inflammation in rats modeling non-obese type 2 diabetes. The research highlights a potential role for omega-3 fatty acids in cases where obesity is not a factor.

Researchers at institutions including the Butantan Institute gave Goto-Kakizaki rats fish oil three times a week for eight weeks. The dose equaled 2 grams per kilogram of body weight and contained specific amounts of EPA and DHA. Treated animals showed lower insulin resistance, improved blood sugar control, reduced inflammatory markers, and better cholesterol and triglyceride levels.

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Illustration of laboratory mice demonstrating effects of a sucrose-free diet on glucose tolerance and gut health.
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Mice on sucrose-free low-fat diet showed impaired glucose control and gut inflammation, researchers report

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Eliminating sucrose from a low-fat diet worsened glucose tolerance and altered the gut microbiome in mice over 16 weeks, according to results presented on Saturday, June 13, 2026, at ENDO 2026, the Endocrine Society’s annual meeting in Chicago.

A two-year clinical trial has shown that high-dose omega-3 fish oil supplements do not improve memory or slow brain changes linked to Alzheimer's disease. The research involved 365 older adults at elevated risk for the condition. Results challenge widespread claims about the supplements' protective effects.

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New research from Yale shows that oleic acid, the main fat in olive oil, accelerated tumor growth in mice prone to pancreatic cancer, while omega-3 fats from fish oil cut disease development by half.

A compound called obakulactone eased swelling and tissue damage in a rat model of rheumatoid arthritis and appeared to work by triggering the breakdown of a metabolic enzyme, ACOT1, researchers reported in the journal Engineering.

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A small clinical trial found that short periods of calorie restriction lowered inflammation markers tied to gum disease. Researchers at King's College London led the study involving patients in Spain. The results suggest dietary changes could complement standard dental treatments.

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