Researchers question vitamin B12 levels and cancer links

Scientists are raising new questions about the relationship between vitamin B12 and cancer risk. While deficiency has long been known to increase dangers, recent studies suggest very high levels may also play a role.

Vitamin B12 supports red blood cell production, DNA repair and nerve function. It occurs naturally in meat, fish, eggs and dairy, with some people relying on fortified foods or supplements. Most individuals on varied diets get enough, though vegans, older adults and those with absorption issues may need extra intake.

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A doctor discussing the risks of biotin supplements with a cancer patient in a medical office, highlighting potential issues with blood tests.
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Doctors warn biotin supplements can interfere with some cancer-related blood tests

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Some cancer patients take biotin supplements hoping to improve hair and nail growth, but specialists at Ohio State University Wexner Medical Center warn that high-dose biotin can interfere with certain blood tests used in cancer monitoring, potentially producing misleading results that could affect follow-up care.

A University of California San Francisco study has linked lower but still normal levels of active vitamin B12 to slower thinking and white matter damage in healthy older adults. The research, published in Annals of Neurology in 2025, suggests current guidelines may miss early neurological risks. Researchers examined 231 participants with an average age of 71.

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A new Japanese study has connected deficiencies in vitamin B12 and folate to increased fatigue and lower motivation in otherwise healthy adults. The research examined blood markers and self-reported symptoms in around 600 participants.

Preliminary research from USC Norris Comprehensive Cancer Center, presented at the American Association for Cancer Research (AACR) annual meeting, found that non-smokers diagnosed with lung cancer before age 50 reported eating more fruits, vegetables and whole grains—and had higher overall Healthy Eating Index scores—than the U.S. population average. The researchers emphasized that the results do not prove diet causes lung cancer and said a possible explanation could involve environmental exposures such as pesticides, a hypothesis that requires direct testing.

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Scientists at the University of Southern Denmark and Odense University Hospital have identified a previously unknown virus inside the common gut bacterium Bacteroides fragilis that appears more frequently in people with colorectal cancer. The finding, detailed by lead researcher Flemming Damgaard, resolves a long-standing paradox since the bacterium is also present in healthy individuals. While the link is strong, the virus's role in causing cancer remains unproven.

Katie Wells, founder of Wellness Mama, argues that many people suffer from low sodium levels despite mainstream advice to restrict salt. She highlights sodium's role in cellular energy, hydration, and nervous system function based on personal experience and research. Wells urges a shift from restriction to optimization, especially for active lifestyles.

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A study involving 73 people with mild cognitive impairment or early dementia found that tailored treatment plans targeting nutritional deficiencies, infections and other factors led to significant cognitive improvements after nine months. Participants in the intervention group saw their overall cognitive scores rise by 13.7 points, while the control group declined by 4.5 points. The approach combines medical interventions with lifestyle changes like diet, exercise and cognitive training.

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