Study finds coffee improves mood through gut bacteria

Both caffeinated and decaffeinated coffee can boost mood and mental performance by influencing gut microbes. Researchers found that polyphenols in coffee drive many of these benefits. The findings come from a controlled trial involving 62 healthy adults.

John Cryan at University College Cork led the study with colleagues from Italy. Participants included regular coffee drinkers and non-drinkers. Regular users stopped coffee for two weeks before resuming either regular or decaf versions for three weeks. Scientists tracked changes through blood, saliva, urine and stool samples along with mood and cognition tests.

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Illustration of a lab mouse showing brain changes from childhood junk food diet, with helpful bacteria depicted.
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Childhood junk food may leave lasting changes in brain circuits that guide eating, mouse study suggests

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Researchers at APC Microbiome Ireland at University College Cork report that early-life exposure to a high-fat, high-sugar diet altered feeding behavior and appetite-related brain pathways in mice into adulthood, even after the animals returned to a standard diet and normal body weight. The team also found that a specific Bifidobacterium strain and a prebiotic fiber mix helped mitigate some of these long-term effects.

A recent study has uncovered additional health benefits of coffee, including its effects on the microbiome, inflammation, and mood. The research shows that regular consumption influences the gut-brain axis, with even decaf offering perks. These findings highlight interactions beyond caffeine's stimulant properties.

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Researchers at the National University of Singapore’s Yong Loo Lin School of Medicine report that caffeine helped reverse sleep deprivation-related deficits in social recognition memory in laboratory mice, an effect tied to synaptic function in the hippocampal CA2 region. The findings were published in the journal Neuropsychopharmacology.

A small 2023 study of adults with obesity in China found that an intermittent energy restriction program was associated with weight loss and changes in gut bacteria alongside altered activity in brain regions linked to appetite, cravings and self-control.

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A new suggestion from Sprudge Coffee proposes that grapefruit juice could extend the duration of caffeine's effects.

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