استخدمت دراسة في مجلة Molecular Psychiatry التصوير بتقنية PET مع مادة تتبع جديدة لتتبع التغييرات في مستقبلات الغلوتامات من نوع AMPA لدى الأشخاص المصابين بالاكتئاب المقاوم للعلاج الذين يتلقون الكيتامين، مشيرة إلى أن التغييرات الخاصة بالمناطق في المستقبلات ارتبطت بتحسن الأعراض.
اضطراب الاكتئاب الشديد هو أحد الأسباب الرئيسية للإعاقة في جميع أنحاء العالم، وأقلية كبيرة نسبيًا من المرضى لا يستجيبون بشكل كافٍ للعلاجات المضادة للاكتئاب القياسية،ن
الردود الأولية على X على دراسة PET التي تربط التأثيرات المضادة للاكتئاب السريعة للكيتامين بتغييرات خاصة بالمناطق في مستقبلات AMPA إيجابية بشكل رئيسي بين علماء الأعصاب وحسابات العلوم، مشيدة بالرؤى الآلية من التصوير البشري. تناقش خيوط مفصلة الآثار على مرونة الدماغ ومقارنات مع نتائج كوفيد طويل الأمد. يعبر طبيب نفسي واحد عن تشكيك في الضجة حول الكيتامين.
A new PET study in patients with treatment-resistant depression suggests something important - ketamine does not just act generally on glutamate - it appears to reshape AMPA receptor density in specific brain circuits. @DavidJoffe64 🧵
— Zdenek Vrozina (@ZdenekVrozina) ٦ مارس ٢٠٢٦
Scientists have directly observed how ketamine improves treatment resistant depression using advanced PET brain imaging.
— SciTech Era (@SciTechera) ٨ مارس ٢٠٢٦
In new study, researchers scanned 34 patients with treatment-resistant depression and 49 healthy individuals.
Using a specialized PET tracer called [¹¹C]K-2,… pic.twitter.com/AfmfNQjJtw
Nice !
— Marco Pignatelli (@Pignatelli_Lab) ٥ مارس ٢٠٢٦
The dynamics of AMPA receptors underlies the efficacy of ketamine in treatment resistant patients with depression | Molecular Psychiatry https://t.co/Wa0T4sKkL0
Thnx for this summary @ZdenekVrozina.
— Tom Molmans, MD (@Molbaas) ٧ مارس ٢٠٢٦
This group already showed different AMPA-receptor density and distribution in depression (localized differences/downregulation)
compared to LC (diffuse upregulation) before,
unrelated to this ketamine-hype.
1https://t.co/CLnPeVvRw0 https://t.co/D1DOZEz7IK
The dynamics of AMPA receptors underlies the efficacy of ketamine in treatment resistant patients with depression https://t.co/lbaHQ8n1Lb
— Nat Rev Neurology (@NatRevNeurol) ٦ مارس ٢٠٢٦
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