『Molecular Psychiatry』に掲載された研究では、新しいトレーサーを用いたPET画像診断により、ケタミン投与を受けた治療抵抗性うつ病患者におけるAMPA型グルタミン酸受容体の変化を追跡し、領域特異的な受容体変化が症状改善と関連していることを報告した。
重度うつ病は世界中で障害の主要な原因であり、患者の相当な少数が標準的な抗うつ薬治療に十分に応答しないのです。
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Researchers studying young adults with major depressive disorder have reported an unusual energy “signature” in both the brain and immune blood cells: higher ATP-related measures at rest, paired with a reduced ability to increase energy production when demand rises. The findings, published in Translational Psychiatry, may help explain common symptoms such as fatigue and low motivation, though the work is early and based on a small sample.
Researchers report designing and testing five fluorinated, reversible carbamate derivatives of psilocin—psilocybin’s active metabolite—aimed at reducing acute psychedelic-like effects while preserving key serotonin-receptor activity. In experiments in mice, a lead compound labeled 4e produced lower but longer-lasting brain exposure to psilocin-related activity and triggered fewer head-twitch responses than pharmaceutical-grade psilocybin, according to a study in the Journal of Medicinal Chemistry.
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A new review of clinical trials suggests that psychedelics like psilocybin are effective for treating depression but offer no advantage over traditional antidepressants. Researchers accounted for the challenge of blinding in psychedelic studies, where participants can often tell if they received the drug. The findings indicate similar outcomes when compared to unblinded antidepressant trials.
MRI scans of 120 adults in the United States found that people with higher psychopathic traits had a striatum—an area involved in reward and motivation—that was about 10% larger on average than those with few or no such traits, according to a study in the Journal of Psychiatric Research.
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Researchers have conducted the first quantitative study on post-game depression, concluding that role-playing games trigger the strongest feelings compared to other genres. The study, involving 373 participants, was published in the Current Psychology journal. RPG completers showed stronger depressive symptoms and emotional processing disturbances.