新たな研究によると、重症のCOVID-19やインフルエンザは肺の免疫細胞を変え、数ヶ月から数年後にがんリスクを高める可能性がある。バージニア大学の科学者らによるこの研究は、このプロセスにおける慢性炎症の役割を強調し、予防策としてワクチン接種を挙げている。結果は、影響を受けた患者の早期発見のためのより密接なモニタリングを提案している。
バージニア大学（UVA）ヘルスのBeirne B. Carter Center for Immunology ResearchおよびUVA Comprehensive Cancer Centerの研究者らは、重症の呼吸器感染症と肺がんリスクの上昇との関連を明らかにした。UVA医学校のJie Sun博士（PhD）をリーダーに、チームはCOVID-19やインフルエンザなどの感染が肺の健康に長期的に及ぼす影響を調べた。
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Researchers analyzing immune cells from people with long COVID have identified a distinct molecular state in CD14+ monocytes—labeled “LC-Mo”—that was more prevalent among patients whose initial COVID-19 illness was mild to moderate and that tracked with reported fatigue and respiratory symptoms, along with higher levels of inflammatory signaling molecules in blood plasma.
Researchers at the University of California, San Francisco have identified how aging lungs contribute to severe flu and COVID-19 outcomes in older adults. Their study shows that lung fibroblasts trigger excessive inflammation, forming damaging clusters of immune cells. The findings, published in Immunity on March 27, suggest potential new treatments.
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