Terpenos da cannabis aliviam a dor em modelos de camundongos sem causar efeitos psicoativos

Pesquisadores da Universidade do Arizona descobriram que certos compostos da planta cannabis podem reduzir a dor crônica em testes pré-clínicos. Os terpenos funcionaram em modelos de fibromialgia e dor pós-cirúrgica sem produzir efeitos psicoativos.

O estudo, publicado na Pharmacological Reports, testou quatro terpenos comumente encontrados na Cannabis sativa: geraniol, linalol, beta-cariofileno e alfa-humuleno. Todos os quatro reduziram as respostas à dor em camundongos, sendo que o geraniol apresentou o efeito mais forte. John Streicher, professor do Departamento de Farmacologia da universidade, afirmou que os compostos não parecem úteis para dores agudas, mas trazem benefícios claros em quadros de dor crônica ou patológica. Os efeitos foram associados ao receptor de adenosina A2a. A fibromialgia afeta até 5 por cento da população global e cerca de 4 milhões de adultos nos Estados Unidos. Os pesquisadores observaram que as opções de tratamento atuais permanecem limitadas. O trabalho contou com o apoio dos National Institutes of Health.

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