Cannabisterpener lindrar smärta i musmodeller utan att ge rus

Svenska

Forskare vid University of Arizona har upptäckt att vissa föreningar från cannabisplantan kan reducera kronisk smärta i prekliniska tester. Terpenerna fungerade i modeller för fibromyalgi och postoperativ smärta utan att ge psykoaktiva effekter.

Studien, som publicerats i Pharmacological Reports, testade fyra terpener som vanligtvis förekommer i Cannabis sativa: geraniol, linalool, beta-karyofyllen och alfa-humulen. Alla fyra minskade smärtresponsen hos möss, där geraniol uppvisade den starkaste effekten. John Streicher, professor vid universitetets institution för farmakologi, uppgav att föreningarna inte verkar användbara vid akut smärta men ger tydliga fördelar vid kroniska eller patologiska smärttillstånd. Effekterna kopplades till adenosin A2a-receptorn. Fibromyalgi drabbar upp till 5 procent av världens befolkning och cirka 4 miljoner vuxna i USA. Forskarna noterade att nuvarande behandlingsalternativ förblir begränsade. Arbetet stöddes av National Institutes of Health.

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