Forskare har identifierat en molekylär strömbrytare som begränsar kliande

Forskare har upptäckt en nervsignal som involverar molekylen TRPV4, vilken talar om för hjärnan när det räcker att klia sig för att få lindring. Experiment på möss visade att utan denna signal blir kliperioderna utdragna, även om den totala frekvensen minskar.

Upptäckten kommer från studier ledda av Roberta Gualdani vid universitetet i Louvain i Bryssel. Hennes team fann att TRPV4-kanaler i sensoriska neuroner bidrar till att aktivera en negativ återkopplingsmekanism i nervsystemet. Denna mekanism informerar ryggmärgen och hjärnan om att kliandet har gett tillfredsställelse, vilket får beteendet att upphöra.

Relaterade artiklar

Scientific illustration showing intestinal tuft cells signaling the brain via acetylcholine, serotonin, and the vagus nerve to suppress appetite during parasitic infections.
Bild genererad av AI

Intestinal cells signal brain to curb hunger during parasitic infections

Rapporterad av AI Bild genererad av AI

A team led by David Julius, the 2021 Nobel Prize winner in Medicine, has described the molecular mechanism by which intestinal tuft cells signal the brain to suppress appetite during parasitic infections. Published today in Nature, the study identifies communication via acetylcholine and serotonin that activates the vagus nerve. The finding could aid treatments for conditions like irritable bowel syndrome.

Researchers at the University of Colorado Boulder have pinpointed a brain region called the caudal granular insular cortex, or CGIC, that acts as a switch turning acute pain into chronic pain. In animal studies, disabling this circuit prevented chronic pain from developing or reversed it once established. The findings, published in the Journal of Neuroscience, open paths to new treatments beyond opioids.

Rapporterad av AI Faktagranskad

Researchers at the University of Technology Sydney report that inducing localized inflammation in a striatal region involved in action selection pushed rats toward more goal-directed, outcome-sensitive behavior rather than automatic habits. The team traced the effect to disrupted astrocyte function, a finding they say could inform future approaches to compulsive disorders such as OCD and addiction.

Researchers working with the University of Auckland and Brazil’s University of São Paulo report that neurons in the medulla’s lateral parafacial (pFL) region—best known for helping drive forceful exhalations—also amplify sympathetic nerve activity and can raise blood pressure in an animal model of neurogenic hypertension. Inhibiting these neurons lowered blood pressure toward normal in hypertensive rats, findings published in Circulation Research.

Rapporterad av AI

Researchers at UCLA Health and UC San Francisco have identified a natural defense mechanism in brain cells that helps remove toxic tau protein, potentially explaining why some neurons resist Alzheimer's damage better than others. The study, published in Cell, used CRISPR screening on lab-grown human neurons to uncover this system. Findings suggest new therapeutic avenues for neurodegenerative diseases.

Denna webbplats använder cookies

Vi använder cookies för analys för att förbättra vår webbplats. Läs vår integritetspolicy för mer information.
Avböj