Forskare har identifierat ett tidigare okänt signalnätverk mellan tarmen och hjärnan som upptäcker proteinbrist och styr ätbeteendet mot livsviktiga aminosyror.
Ett team lett av direktör SUH Seong-Bae vid Institute for Basic Science, tillsammans med kollegor från Seoul National University och Ewha Womans University, har kartlagt mekanismen hos bananflugor och bekräftat ett liknande beteende hos möss. Arbetet publicerades i tidskriften Science den 21 maj.
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Researchers at APC Microbiome Ireland at University College Cork report that early-life exposure to a high-fat, high-sugar diet altered feeding behavior and appetite-related brain pathways in mice into adulthood, even after the animals returned to a standard diet and normal body weight. The team also found that a specific Bifidobacterium strain and a prebiotic fiber mix helped mitigate some of these long-term effects.
A new study shows that oral GLP-1 receptor agonists can curb pleasure-driven eating in mice by acting on a brain reward circuit. The research, supported by the National Institutes of Health, examined drugs including orforglipron and danuglipron.
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A study from the Monell Chemical Senses Center reports that, calorie for calorie, fructose and glucose engage different gut–brain pathways in mice. The researchers found glucose more strongly suppresses activity in hunger-related AgRP neurons, while fructose produces a weaker effect through a pathway involving the gut hormone PYY and signaling via the vagus nerve.
An international research team has published the first complete map of neural connections spanning the brain and nerve cord of an adult fruit fly. The work reveals that many behaviors arise from distributed local circuits rather than centralized brain control. The connectome was released June 8 in the journal Nature.
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A year-long observational study in Japan suggests that people with type 2 diabetes who tend to overeat in response to tempting food cues such as sight and smell may see greater weight loss—and possibly better blood-sugar improvement—after starting GLP-1 receptor agonists, while those with primarily emotional eating patterns show less consistent links to long-term outcomes.