Serotonin kan förvärra symtom vid tinnitus enligt ny studie

Ny forskning visar att serotonin, en signalsubstans i hjärnan som ökar av många antidepressiva läkemedel, kan intensifiera tinnitus. Forskare har identifierat ett specifikt nervbanesystem hos möss som kopplar högre serotoninnivåer till beteenden som efterliknar tillståndet med ringande ljud.

Ett forskarlag från Oregon Health & Science University och Anhui University i Kina har publicerat resultaten i Proceedings of the National Academy of Sciences. De använde optogenetik för att stimulera serotoninproducerande nervceller och observerade ökad aktivitet i hjärnans hörselcentrum, tillsammans med tinnitusliknande reaktioner hos mössen via ett modifierat starttest. Studien bygger vidare på tidigare forskning från 2017 och stämmer överens med rapporter från vissa patienter vars tinnitus förvärras av SSRI-preparat.

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