高齢マウスの筋幹細胞を若返らせることで、筋肉の成長が促進され、損傷後の回復力が向上することが研究で明らかになった。この手法は将来、高齢者が筋力や運動機能を取り戻す助けになる可能性がある。実験では、脚の機能や組織修復において明確な改善効果が示された。
デューク大学の研究チームは、高齢マウスから筋幹細胞を採取し、特定の脂質を加えて実験室で培養した後、損傷した他の高齢マウスの筋肉に注入した。その結果、処理された細胞から生成された新しい筋繊維は、未処理の細胞から生成されたものよりも45％大きく、マウスは数日以内にトレッドミルや運動機能テストで良好なパフォーマンスを示した。
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Researchers at City of Hope report that aging can spur the emergence of an age-enriched population of adipose progenitor cells that is especially prone to generating new fat cells in abdominal white fat. The work, published in Science, points to a signaling pathway that may help drive midlife increases in belly fat and could become a future therapeutic target.
Researchers at Texas A&M University have shown that mammals may possess dormant abilities to regrow complex body parts. A new two-step treatment redirected healing in mice away from scarring toward tissue regeneration. The approach restored bone, joints, ligaments and tendons after amputation.
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Researchers at UCLA have identified senescent immune cells, dubbed 'zombie' cells, that accumulate in aging livers and contribute to fatty liver disease. By eliminating these cells in mice, the team reversed liver damage and reduced body weight, even on an unhealthy diet. The findings, published in Nature Aging, suggest similar mechanisms may drive human liver conditions.
Researchers at Marshall University report that microscopic particles found in the gut lumen—known as exosomes—differ between young and old mice and can influence metabolism and gut-barrier function when transferred between animals. The findings, published in the journal Aging Cell, suggest these particles may help drive biological changes associated with aging, though the work is preclinical.
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Researchers in Japan have created new vitamin K compounds that are three times more effective than natural forms at turning stem cells into neurons. The work, published in 2025, targets diseases that destroy brain cells such as Alzheimer’s and Parkinson’s.