Studie kopplar vanliga läkemedel mot IBS till högre långsiktig dödlighetsrisk

16 april 2026

Rapporterad av AI

Forskare vid Cedars-Sinai har analyserat nästan 20 års journaler från över 650 000 amerikanska vuxna med irritabel tarm (IBS) och funnit samband mellan vissa läkemedel och ökad dödlighet. Antidepressiva läkemedel kopplades till en 35 procent högre risk för dödsfall, medan loperamid och difenoxylat uppvisade ungefär dubbelt så hög risk jämfört med icke-användare. Andra IBS-behandlingar, såsom FDA-godkända läkemedel och kramplösande medel, visade ingen sådan ökning.

Studien, som publicerats i Communications Medicine, undersökte den långsiktiga säkerheten för behandlingar mot IBS, ett kroniskt tillstånd som drabbar cirka 10 procent av amerikanerna. Forskningen leddes av Ali Rezaie, MD, medicinsk chef för GI Motility Program vid Cedars-Sinai, och fyllde en kunskapslucka som lämnats av kortsiktiga kliniska prövningar, vilka vanligtvis varar mindre än ett år trots att patienter ofta använder medicinerna i årtionden. Rezaie konstaterade: ”Många patienter diagnostiseras med IBS i ung ålder och kan förbli medicinerade i åratal.”

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