Pesquisadores da McGill identificam interruptor acionado por glicerol que ativa uma segunda via de produção de calor na gordura marrom

12 de maio de 2026

Reportado por IA

Verificado

Cientistas da Universidade McGill relatam que o glicerol liberado durante a quebra de gordura induzida pelo frio pode ativar a enzima fosfatase alcalina inespecífica de tecido (TNAP), acionando uma via de dissipação de energia baseada em creatina na gordura marrom. As descobertas foram publicadas em 12 de maio de 2026 na revista Nature e também podem orientar pesquisas sobre doenças ósseas ligadas à TNAP.

Cientistas da Universidade McGill afirmam ter identificado um gatilho molecular que ativa uma via alternativa de produção de calor na gordura marrom, o tecido gerador de calor envolvido na manutenção da temperatura corporal.

De acordo com um comunicado da Universidade McGill distribuído pelo ScienceDaily, a equipe descobriu que o glicerol — produzido quando a gordura armazenada é decomposta durante a exposição ao frio — liga-se e ativa a fosfatase alcalina inespecífica de tecido (TNAP). Os pesquisadores relatam que essa ativação liga o chamado “ciclo fútil da creatina”, um processo dependente de creatina que pode dissipar energia e gerar calor juntamente com o mecanismo termogênico mais conhecido na gordura marrom.

O trabalho, publicado na Nature em 12 de maio de 2026, também vincula o mecanismo à biologia óssea. A TNAP é amplamente reconhecida por seu papel na mineralização óssea, e os pesquisadores argumentam que entender como o glicerol influencia a TNAP pode ajudar a orientar futuros estudos de doenças ósseas ligadas à redução da atividade da TNAP, incluindo a hipofosfatasia.

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quarta-feira, 06 de maio de 2026, 01:14h

Pesquisadores da McGill identificam interruptor acionado por glicerol que ativa uma segunda via de produção de calor na gordura marrom

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