Estudo descobre que traços epigenéticos quebram as leis genéticas de Mendel

Um estudo financiado pelo governo federal em camundongos revelou que alguns traços hereditários seguem padrões não mendelianos por meio de mudanças epigenéticas. A pesquisa identificou centenas de eventos inesperados de metilação do DNA entre gerações. Também documentou a primeira paramutação natural conhecida em um mamífero.

Pesquisadores da Johns Hopkins University e da Texas A&M University rastrearam a metilação do DNA em três gerações de camundongos. Eles examinaram 12 padrões de herança conhecidos e descobriram que cerca de 7 por cento não seguiam as regras mendelianas clássicas. Entre esses, houve 54 casos em que a metilação apareceu na descendência sem estar presente em nenhum dos pais.

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