Infecção pelo VSR em camundongos previne a disseminação do câncer de mama para os pulmões

Pesquisadores descobriram que infectar camundongos com o vírus sincicial respiratório (VSR) reduziu a capacidade das células de câncer de mama de formar tumores nos pulmões em 65 a 70 por cento. O efeito decorre dos interferons do tipo I, proteínas que combatem a replicação viral e dificultam a fixação das células cancerígenas. O estudo traz esperanças para o desenvolvimento de medicamentos que imitem esse mecanismo.

Cientistas do Imperial College London infectaram 23 camundongos via intranasal com o VSR, um vírus que causa sintomas semelhantes aos de um resfriado, enquanto 16 camundongos do grupo de controle receberam solução salina. Vinte e quatro horas depois, todos os camundongos foram injetados com células de câncer de mama. Após 28 dias, o grupo infectado com VSR apresentou de 65 a 70 por cento menos nódulos tumorais nos pulmões em comparação com o grupo de controle, embora o tamanho dos nódulos fosse semelhante em ambos os grupos, indicando que o vírus bloqueia principalmente a fixação inicial e não o crescimento. Cecilia Johansson, a pesquisadora principal, classificou os resultados como 'muito empolgantes', observando que nenhum estudo anterior havia demonstrado esse efeito. Ela afirmou: 'Isso é muito empolgante; nenhum estudo mostrou o que nós mostramos.'

Artigos relacionados

Realistic depiction of a long COVID patient experiencing fatigue and breathing difficulties, overlaid with highlighted CD14+ monocytes (LC-Mo state) and inflammatory markers from recent immune study.
Imagem gerada por IA

Study links a distinct CD14+ monocyte state to fatigue and breathing symptoms in long COVID

Reportado por IA Imagem gerada por IA Verificado

Researchers analyzing immune cells from people with long COVID have identified a distinct molecular state in CD14+ monocytes—labeled “LC-Mo”—that was more prevalent among patients whose initial COVID-19 illness was mild to moderate and that tracked with reported fatigue and respiratory symptoms, along with higher levels of inflammatory signaling molecules in blood plasma.

New research indicates that severe cases of COVID-19 or influenza can alter lung immune cells, potentially increasing cancer risk months or years afterward. The study, conducted by scientists at the University of Virginia, highlights the role of chronic inflammation in this process and emphasizes vaccination as a preventive measure. Findings suggest closer monitoring for affected patients to enable early detection.

Reportado por IA

Scientists have harvested antibodies from the blood of paediatricians to develop new preventative treatments for respiratory syncytial virus (RSV) and human metapneumovirus. These antibodies outperform existing therapies by up to 25 times and target a wider range of strains. The discovery stems from the natural immunity built by paediatricians through years of exposure to respiratory viruses.

Researchers at Northwestern University have developed a more effective therapeutic vaccine for HPV-related cancers by rearranging components in a DNA-based nanoparticle. This structural adjustment significantly enhances the immune system's ability to target and destroy tumors. The findings, published in Science Advances, highlight the importance of molecular arrangement in vaccine design.

Reportado por IA

Scientists at Johns Hopkins have found that Fusobacterium nucleatum, a bacterium associated with gum disease, can travel to breast tissue via the bloodstream, causing DNA damage and accelerating tumor growth and spread. The effect is particularly pronounced in cells with BRCA1 mutations. The research highlights a potential connection between oral health and breast cancer risk.

Researchers have identified a new class of orphan non-coding RNAs, called oncRNAs, that appear across various cancer types and form unique molecular signatures. These molecules not only identify cancer type and subtype with high accuracy but also drive tumor growth in some cases. Their presence in the bloodstream offers potential for simple blood tests to monitor treatment response and predict patient survival.

quarta-feira, 22 de abril de 2026, 08:33h

Researchers discover virus in gut bacteria tied to colorectal cancer

sexta-feira, 03 de abril de 2026, 07:13h

AI identifies breast cancer drug for multiple viruses

sexta-feira, 03 de abril de 2026, 03:43h

UCSF study explains severe flu and COVID in older adults

sábado, 21 de março de 2026, 16:37h

UNIGE researchers unveil AI tool predicting cancer metastasis

sábado, 21 de março de 2026, 06:24h

Scientists engineer probiotic bacteria to target mouse tumors

sexta-feira, 20 de março de 2026, 03:50h

Virus therapy enhances immune attack on glioblastoma

terça-feira, 10 de março de 2026, 13:21h

Scientists develop molecule to target aggressive breast cancer

segunda-feira, 23 de fevereiro de 2026, 04:28h

Stanford scientists develop universal nasal spray vaccine

sexta-feira, 13 de fevereiro de 2026, 21:26h

Oldest cold virus identified in 18th-century woman's lungs

quarta-feira, 11 de fevereiro de 2026, 05:11h

FDA fast-tracks first inhalable gene therapy for lung cancer

Este site usa cookies

Usamos cookies para análise para melhorar nosso site. Leia nossa política de privacidade para mais informações.
Recusar