RSV-infektion hos möss förhindrar bröstcancerns spridning till lungorna

Forskare har funnit att infektion med RS-virus (RSV) hos möss minskade bröstcancercellers förmåga att bilda tumörer i lungorna med 65 till 70 procent. Effekten beror på typ I-interferoner, proteiner som bekämpar virusreplikation och hindrar cancerceller från att få fäste. Studien ger hopp om läkemedel som kan efterlikna denna mekanism.

Forskare vid Imperial College London infekterade 23 möss intranasalt med RSV, ett virus som orsakar förkylningsliknande symptom, medan 16 kontrollmöss fick koksaltlösning. Tjugofyra timmar senare injicerades alla möss med bröstcancerceller. Efter 28 dagar uppvisade RSV-gruppen 65 till 70 procent färre tumörknölar i lungorna jämfört med kontrollgruppen, även om knölarnas storlek var liknande i båda grupperna, vilket tyder på att viruset främst blockerar den initiala etableringen snarare än tillväxten. Cecilia Johansson, huvudforskare för studien, beskrev resultaten som 'mycket spännande' och påpekade att ingen tidigare studie har visat denna effekt. Hon sade: 'Det här är mycket spännande; ingen studie har visat det vi har visat.'

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