Forskare lanserar BRIDGE-projekt om aggressiv bröstcancer

Forskare från ITQB NOVA och det portugisiska onkologiska institutet (IPOFG) har inlett BRIDGE-projektet för att kartlägga hur aggressiv bröstcancer undgår immunsystemet. Initiativet syftar till att hitta biomarkörer för bättre prognoser gällande sjukdomsförloppet samt för att möjliggöra personliga behandlingar. Projektet, som finansieras med upp till 75 000 euro, sträcker sig över två år och använder patientprover för att validera laboratoriefynd.

BRIDGE-projektet, en förkortning av Biomarker Research Integrating Data of Glyco-Immune Signatures and Clinical Evidence in Breast Cancer, fokuserar på tumörens mikromiljö där cancerceller interagerar med immunceller. Forskarna strävar efter att identifiera små molekyler på cellytor som gör det möjligt för tumörer att dölja sig för immunsystemet, vilket leder till okontrollerad tillväxt. Detta bygger på tidigare upptäckter om kommunikationen mellan tumörer och immunförsvaret, som nu testas med hjälp av faktiska patientprover från IPOFG.

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