Pesquisadores lançam projeto BRIDGE sobre câncer de mama agressivo

Cientistas do ITQB NOVA e do Instituto Português de Oncologia iniciaram o projeto BRIDGE para descobrir como o câncer de mama agressivo evade o sistema imunológico. A iniciativa busca biomarcadores para uma melhor previsão da progressão da doença e tratamentos personalizados. Financiado com até 75.000 euros, o esforço de dois anos utiliza amostras de pacientes para validar as descobertas laboratoriais.

O projeto BRIDGE, sigla para Biomarker Research Integrating Data of Glyco-Immune Signatures and Clinical Evidence in Breast Cancer (Pesquisa de Biomarcadores Integrando Dados de Assinaturas Glico-Imunes e Evidências Clínicas em Câncer de Mama), tem como alvo o microambiente tumoral onde as células cancerígenas interagem com as células imunológicas. Os pesquisadores pretendem identificar pequenas moléculas na superfície das células que permitem aos tumores suprimir a detecção imunológica, levando ao crescimento descontrolado. Isso se baseia em descobertas anteriores sobre a comunicação tumor-imunidade, agora testadas com amostras reais de pacientes do IPOFG.

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